01 January 1999
Effect of angiotensin converting inhibitors (ACEI) on lipid peroxidation and antioxidative enzymes activities in experimental diabetesKornelia Z. Kędziora-Kornatowska, Marek Luciak, Jan Błaszczyk, Wojciech Pawlak
Med Sci Monit 1999; 5(1): BR16-20 :: ID: 505189
We evaluated the effect of two angiotensin converting enzyme inhibitors, enalapril and captopril, on erythrocyte lipid peroxidation and superoxide dismutase and catalase activities in rats with streptozotocin-induced diabetes. A progressive increase in the level of malondialdehyde (MDA) and a decrease in superoxide dismutase (SOD) and catalase activities had been observed in diabetic rats following 6 and 12 weeks, indicative of erythrocytes oxidative stress in experimental diabetes. Captopril (2 mg/kg body weight) increased the diabetic-induced changes of MDA content and SOD activity following 6 weeks and inhibited them after 12 weeks, as well as prevented the decrease in catalase activity following both 6 and 12 weeks. Enalapril (1 mg/kg body weight) counteracted the diabetic-induced changes of MDA content, SOD and catalase activities following both 6 and 12 weeks. These results suggest the possibility of a therapeutic use of ACE-inhibitors in order to attenuate the effects of oxidative stress in diabetes.
Keywords: Lipid Peroxidation, Lipid Peroxidation, enalapril, diabetes
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