Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1999

Hypolipemic diet effect on lipoprotein profile in patients with hypercholesterolaemia and mixed hyperlipidaemia in relation to apo E phenotype

Longina Kłosiewicz-Latoszek, Grażyna Nowicka, Agnieszka Grzybek, Barbara Grzybowska, Janina Paluszkiewicz, Julita Szonert, Lucyna Pachocka, Elżbieta Murakowska, Irena Stolarska

Med Sci Monit 1999; 5(1): CR62-70 :: ID: 505223


The aim of our study was to assess the effect of a hypolipaemic diet on serum lipoproteins and apolipoprotein B and lipoprotein (a) in relation to the apo E phenotype. Material and methods: Subjects were drawn from the Outpatient Clinic of Metabolic Diseases. From 210 patients enrolled to the study, 188 completed it. In studied group the frequency of various apo E phenotypes was: apo E2/2 - 1.1%, apo E2/3 - 10.6%, E 2/4 - 3.2%, E3/3- 66.5%, E3/4 - 15.9% and E4/4 - 2.7%. The diet of patients was composed of reduced content of total fat, saturated fatty acids and cholesterol. Results: The daily energy consumption decreased from 7853 kJ (1877 kcal) to 5954 kJ (1423 kcal). Total fat intake declined from 35.3% to 32.3%, saturated fatty acids from 11.3% to 9.7%, and cholesterol from 297mg to 173 mg daily. The mean reduction of serum total cholesterol was 9.5% (p<0.001) and LDL cholesterol was 9.2% (p<0.001), and triglycerides - 18.2% (p<0.001) as well as apo B - 4.1% (p<0.05). No significant changes were noted in HDL cholesterol and Lp(a) concentrations. Patients with phenotype E2/4 (20.3%, p<0.05) and E 4/4 (14.4%, p<0.05) evaluated the most significant decrease of cholesterol serum concentrations. Similar trends were noted in the changes of LDL cholesterol. Patients with phenotypes apo E4/4 (33.8%, p<0.05) and E3/3 (18.3%, p<0.001) evaluated the most significant decrease of triglycerides serum concentrations. No association between apo E phenotype and changes in HDL cholesterol and Lp(a) concentrations was found. Conclusion: Our results reveal that patients with E4 allele respond slightly better to hypolipaemic diet than patients with E3 and E2 allele, however the differences are not statistically significant.

Keywords: coronary risk factors, Patients, Lipoproteins, Lipoproteins, phenotype apo E, hypolipaemic diet



01 February 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939580

Med Sci Monit 2023; 29:e939580


19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

10 December 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit 2022; 28:e938647

In Press

07 Feb 2023 : Clinical Research  

Application of Musculoskeletal Ultrasound Guidance in Lumbar Transforaminal Endoscopic Surgery for Puncture...

Med Sci Monit In Press; DOI: 10.12659/MSM.937692  

07 Feb 2023 : Clinical Research  

Effect of Polylactic Acid Membrane on Guided Bone Regeneration in Anterior Maxillary Implantation

Med Sci Monit In Press; DOI: 10.12659/MSM.938566  

06 Feb 2023 : Clinical Research  

Double C-Arm Digital Subtraction Angiography Guidance During Transjugular Intrahepatic Portosystemic Shunt ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938912  

06 Feb 2023 : Review article  

Evolution of Hybrid Intelligence and Its Application in Evidence-Based Medicine: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939366  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750