01 January 1999
Diagnostic value of static perimetry, visual evoked potentials and magnetic resonance imaging in multiple sclerosis patientsMarta Misiuk-Hojło, Anna Turno-Krecicka, Maria Hanna Niżankowska, Maria Ejma
Med Sci Monit 1999; 5(1): CR78-83 :: ID: 505254
Background: The aim of this study was the evaluation of diagnostic clinical tests sensitivity in ophtalmological demyelinating neuropathy.
Material/Methods: The study group comprised 21 patients (38 eyes) with diagnosed sclerosis multiplex (SM) without previous episodes of posterior ophtalmological neuritis in the history of the disease. We performed static perimetry of the central visual field (30 degrees, by Octopus 101), pattern visual evoked potentials (p VEP), color photographs of the optic disc and magnetic resonance imaging (MRI) of the central nervous system, optic nerves and optic chiasm.
Results: Visual acuity and color vision were normal. There was a statistically significant elongation in the latency of P100 during pattern VEP ( > 118 ms, 3x SD) and a significant reduction in mean light sensitivity (MS) of the central visual field. MRI revealed demyelinization in the cortex and/or spinal cord of all patients and a demyelinating lesion in the optic nerve of one patient. There was no Gd-DTPA enhacement. Statical analysis demonstrated no correlation between results of pattern VEP, MRI, morphology of optic discs, duration of SM, stage of the disease (according to Kurtzke's scale), or age of patients. Regression analysis demonstrated statistically significant relationships (p < 0.05) between results of central static perimetry, duration and stage of the disease.
Conclusions: Static perimetry showed reduced sensitivity towards light even in case of full visual acuity and lack of optic nerve disease symptoms. Pattern VEP revealed optic nerve dysfunction prior to the appearance of demyelinization plaques, Record changes are not connected with disease advancement. MRI is only slightly correlated with neurologic and ophthalmologic symptomatology in multiple sclerosis. Functional changes of the optic nerve precede hyperintensive foci in the retrobulbar segment of optic nerves.
Keywords: static perimetry, Multiple Sclerosis, Magnetic Resonance Imaging, visual evoked potentials (VEP)
01 May 2023 : EditorialEditorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy
Med Sci Monit 2023; 29:e940911
31 May 2023 : Review articlePrevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.939919
30 May 2023 : Clinical ResearchA Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...
Med Sci Monit In Press; DOI: 10.12659/MSM.940409
30 May 2023 : Review articleA Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...
Med Sci Monit In Press; DOI: 10.12659/MSM.940550
30 May 2023 : Database AnalysisThe COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland
Med Sci Monit In Press; DOI: 10.12659/MSM.940904
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952