01 January 1999
Serum cytokines concentrations in patients with infective endocarditis. A possible role in diagnosis and monitoring
Irena Rawczyńska-Englert, Tomasz Hryniewiecki, Danuta DzierżanowskaMed Sci Monit 1999; 5(1): CR89-92 :: ID: 505260
Abstract
Introduction: Early diagnosis of infective endocarditis is important for the clinical outcome since mortality increases with a longer diagnostic delay. The diagnosis of infective endocarditis is mainly based on clinical features, echocardiography and blood culture findings. Unfortunately negative blood cultures have been reported in up to 30% of proved cases. The aim of the study was to investigate usefulness of serum cytokines concentrations in diagnosis and monitoring of infective endocarditis.
Material and Method: The study group consisted of 30 patients with acquired rheumatic valvular heart diseases and ongoing infective endocarditis. The diagnosis of infective endocarditis was established on clinical examination, echocardiography, laboratory investigations (inflammatory parameters) and positive blood cultures (in 26 patients). Control group consisted of 10 patients with acquired rheumatic valvular heart diseases without infective endocarditis. Serum interleukin-1a (IL-1a), interleukin-6 (IL-6) and a tumor necrosis factor-a (TNF-a) concentrations were measured three times during antimicrobial treatment (mean interval 16±8 days).
Results: Serum IL-1a and TNF-a concentrations were not elevated in any patient or control (IL-1a<3.9 pg/ml, TNF-a<10 pg/ml - below calibration range). Serum IL-6 concentrations were elevated in all measuring points in patients with infective endocarditis (first: 36.7±48.1, second: 19.2±17.5 third: 8.7±5.7 pg/ml) with a significant tendency to decrease during treatment (ANOVA, p<0.01). In all controls serum IL-6 concentrations were below calibration range (<3.2 pg/ml).
Conclusions: 1. Elevated serum IL-6 concentrations may suggest ongoing infective endocarditis and could be an additional parameter in diagnosis and monitoring treatment of the disease. 2. Serum IL-1a and TNF-a concentrations were not affected. Further understanding the role of serum cytokines concentrations in diagnosing, prognosis and monitoring of infective endocarditis could be useful in clinically uncertain diagnosis especially while blood cultures are negative.
Keywords: Cytokines, infective endocarditis, Diagnosis
Editorial
01 January 2023 : Editorial
Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030DOI: 10.12659/MSM.939357
Med Sci Monit 2023; 29:e939357
SARS-CoV-2/COVID-19
26 January 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadMed Sci Monit In Press; DOI: 10.12659/MSM.939580
19 January 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
In Press
27 Jan 2023 : Database Analysis
Association Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality in Critically Ill Patients with Chr...Med Sci Monit In Press; DOI: 10.12659/MSM.938554
27 Jan 2023 : Clinical Research
Proposal for a Simple Equation for Limb Muscle Weight CalculationMed Sci Monit In Press; DOI: 10.12659/MSM.938606
26 Jan 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadMed Sci Monit In Press; DOI: 10.12659/MSM.939580
20 Jan 2023 : Clinical Research
A Study of 42 Partially Edentulous Patients with Single-Crown Restorations and Implants to Compare Bone Los...Med Sci Monit In Press; DOI: 10.12659/MSM.939225
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952