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Impact of baseline level of 7-ketocholesterol on the rate of coronary reintervention in coronary artery disease patients - results of an observational study with questionnaire-based follow up

Andrzej Tomasik, Wojciech Jacheć, Bronisława Skrzep-Poloczek, Celina Wojciechowska, Roman Tarnawski, Jan Wodniecki, Lech Poloński, Krzysztof Szczurek-Katański

Med Sci Monit 2000; 6(4): CR751-758 :: ID: 508214

Abstract

Introduction: The aim of study was to assess the relation between plasma level of one of the oxysterols Ð 7-ketocholesterol and angiographically evidenced coronary artery disease.
Material and methods: We measured plasma level of 7-ketocholesterol, malondialdehyde, total cholesterol,HDL cholesterol, triglycerides, erythrocyte activity of superoxide dismutase in 233 patients who previously underwent coronary angiography for diagnosis of coronary artery disease. The follow-up of patients (28 months) was done on basis of questionnaires sent out to them.
Results: We found that the subgroup of patients with 7-ketocholesterol above the median value (62 ng/mL) has higher rate of coronary reintervention (8/54 pts vs. 5/43 pts in 7-ketocholesterol below 62 ng/mL respectively, p=0.284 Log-rank test). The finding was more pronounced, yet insignificant, in the subgroup of patients who underwent primary PTCA (6/19 pts vs. 2/20 pts, p=0.1 Log-rank test). There were 3 patients in high 7-ketocholesterol subgroup who entered the study with previously undergone primary coronary intervention. There were not such patients in low 7-ketocholesterol subgroup. 4 deaths were observed in high 7-ketocholesterol subgroup, and one in low 7-ketocholesterol subgroup (they were predominantly not of cardiovascular origin).
Conclusions: We failed to find a significant relation between 7-ketocholesterol and coronary artery disease, though there is a trend of such relation in patients who undergo PTCA, evidenced by a slightly higher number of repeated revascularizations among patients with high 7-ketocholesterol. The study indicates the areas of further studies with agents capable of lowering oxysterols and assessing also other end points.

Keywords: coronary reintervention, coronary artery bypass grafting (CABG), percutaneous transluminal coronary angioplasty (PTCA), Coronary Artery Disease

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750