Background: Non-functioning neuroendocrine pancreatic tumors are usually connected with non-specific syndromes.
Case report: This case history presents the diagnosis and treatment of a non-functioning neuroendocrine pancreatic tumor causing sinistral portal hypertension and gastrointestinal bleeding in a 36-year-old man.
Results: A peripheral resection of the pancreas with splenectomy was performed. Intraoperative examination of the specimen revealed a malignant neoplasm, probably neuroendocrinal carcinoma.
Conclusion: Peripheral resection of the pancreas with splenectomy treats not only the symptoms of segmental portal hypertension caused by pathology of this organ, but also allows the etiology of the disease to be determined.

Keywords: neuroendocrine pancreatic tumors, sinistral portal hypertension, Splenectomy