01 November 2007
The therapeutic effect of Intravenous Immunoglobulins and Vitamin C on the progression of Experimental Autoimmune Myocarditis in the mouse
Fangqi Gong, Yanfang Hu, Liqin Chen, Weizhong GuMed Sci Monit 2007; 13(11): BR240-246 :: ID: 512822
Abstract
Background: The aim was to evaluate the efficacy of intravenous-immunoglobulin (IVIG) and vitamin C (VC) on the progression of experimental autoimmune myocarditis (EAM).
Material/Methods: Fifty-two Balb/c mice were randomized into six groups: blank, small-dosage VC, large-dosage VC, IVIG, IVIG+VC, and a control group. All mice were sacrificed 21 days later. The level of tumor necrosis factor alpha (TNF-alpha), the ratios of the heart, spleen, and kidney to body weight (C/W, S/W, K/W), and pathological changes in the hearts and spleens were evaluated.
Results: VC could extenuate inflammatory cell infiltration in the myocardium and calcification in the pericardium. IVIG or IVIG+VC could extenuate the pathological change more effectively. The C/W of each therapy group decreased significantly compared with that of control group. The TNF-alpha levels in the small- and large-dosage VC groups were a little lower than in the control group; the levels in the IVIG and IVIG+VC groups were significantly lower than in controls. Electron microscopic observation of the myocardium showed that VC could extenuate the damage to the myocardium. The myocardium in IVIG and IVIG+VC groups were almost normal.
Conclusions: IVIG and vitamin C have some protective and therapeutic effect on the progression of EAM by decreasing pathological damage to the myocardium and depressing TNF-alpha production. Especially IVIG combined with vitamin C are more effective as they can stimulate the immune reaction and increase IgG deposition in the myocardium.
Keywords: Tumor Necrosis Factor-alpha - blood, Myocardium - ultrastructure, Myocarditis - therapy, Microscopy, Electron, Transmission, Mice, Inbred BALB C, Immunoglobulins, Intravenous - therapeutic use, Autoimmune Diseases - therapy, Ascorbic Acid - therapeutic use, Ascorbic Acid - therapeutic use, Tumor Necrosis Factor-alpha - blood, Myocardium - ultrastructure, Myocarditis - therapy, Microscopy, Electron, Transmission, Mice, Inbred BALB C, Immunoglobulins, Intravenous - therapeutic use, Autoimmune Diseases - therapy
Editorial
01 February 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadDOI: 10.12659/MSM.939580
Med Sci Monit 2023; 29:e939580
SARS-CoV-2/COVID-19
19 January 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
10 December 2022 : Clinical Research
Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...Med Sci Monit 2022; 28:e938647
In Press
03 Feb 2023 : Clinical Research
Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...Med Sci Monit In Press; DOI: 10.12659/MSM.938865
02 Feb 2023 : Clinical Research
Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...Med Sci Monit In Press; DOI: 10.12659/MSM.938672
02 Feb 2023 : Database Analysis
Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based...Med Sci Monit In Press; DOI: 10.12659/MSM.938785
01 Feb 2023 : Clinical Research
Comparison of 3 Enzyme-Linked Immunoassay Methods to Evaluate Serum Concentrations of Infliximab and Antibo...Med Sci Monit In Press; DOI: 10.12659/MSM.939084
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952