Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

29 January 2008

Coincidence of loci for glucosuria and obesity in type 2 diabetes-prone KK-Ay mice

Jun-ichi SutoABCDEFG

Med Sci Monit 2008; 14(2): CR65-74 :: ID: 734752

Abstract

Background
Colleagues and I previously performed a quantitative trait locus (QTL) analysis on non-insulin-dependent diabetes mellitus (NIDDM) traits (hyperglycemia and glucose intolerance) and body weight (obesity) in KK-Ay mice. QTLs for NIDDM traits were quite different from those for body weight. In this study, I performed a QTL analysis on glucosuria to characterize its genetics and pathophysiology in KK-Ay mice.
Material and Method
Onset and severity of glucosuria were examined at 40 days (UR40), 50 days (UR50), and 60 days (UR60) after birth, and I compared the results with those for NIDDM traits and body weight.
Results
Suggestive QTLs were identified on chromosomes 4 (UR60) and 6 (UR60). Significant QTLs were identified on chromosomes 6 (UR40 and UR50, Guq1), and 16 (UR40, Guq2). At the locus on chromosome 4 and Guq1, the KK allele was associated with increases in glucosuria severity and body weight; on the contrary, the KK allele was associated with decreases in glucosuria severity and body weight at Guq2. With regard to the fasting plasma glucose levels at autopsy, the KK allele at the Guq1 locus was significantly associated with elevated glucose levels, and there was a trend that the KK allele at Guq2 was associated with decreased glucose levels.
Conclusions
Glucosuria is a complex trait that has a strong relationship to body weight rather than to NIDDM traits. A genetic relationship among glucosuria, body weight, and fasting glucose levels was confirmed. Allelism between glucosuria QTL and body weight QTL was strongly suggested.

Keywords: Mice, Inbred Strains, Lod Score, Glycosuria - genetics, Crosses, Genetic, Diabetes Mellitus, Type 2 - genetics, Chromosome Mapping, Quantitative Trait Loci, Obesity - genetics, Body Weight - genetics, Blood Glucose - metabolism

Add Comment 0 Comments

Editorial

01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

Database Analysis  

Long-Term Prognosis of Patients Undergoing Percutaneous Coronary Intervention: The Impact of Serum Creatini...

Med Sci Monit In Press; DOI: 10.12659/MSM.943063  

Database Analysis  

Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern...

Med Sci Monit In Press; DOI: 10.12659/MSM.943601  

Animal Research  

Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats

Med Sci Monit In Press; DOI: 10.12659/MSM.942485  

Clinical Research  

Differential Inflammatory Responses in Adult and Pediatric COVID-19 Patients: Implications for Long-Term Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944052  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750