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01 July 2008

Sex difference in the association of the angiotensin converting enzyme I/D polymorphism and body mass index

Michael J WackerABCDEFG, Michael P GodardACDEFG, Everlee H McCabeBC, Joseph E DonnellyA, John K KellyCDEF

Med Sci Monit 2008; 14(7): CR353-357 :: ID: 863663


Angiotensin converting enzyme (ACE) catayzes the formation of angiotensin I to angiotensin II. A polymorphism has been identified in intron 16 in which a 287 base-pair alu sequence was found to be present (insertion or I) or absent (deletion or D) in the population. ACE and the components of the renin-angiotensin system are expressed in adipose tissue and therefore the I/D polymorphism within ACE may be associated with obesity.
Material and Method
This study involved genotyping two groups with differing body mass indexes (BMI or=30) that were composed primarily of middle-age Caucasian subjects (n=421).
The male groups differed significantly in allele frequency at the ACE locus with the I allele more frequent in the BMI >or=30 group (p<0.05). While the female BMI >or=30 group also had a higher I allele frequency than the BMI Conclusions
Our results demonstrate a sex difference in the association of the I/D polymorphism and BMI. Our findings differ from some other previous studies using various population groups which indicate that the ACE I/D polymorphism may be differentially associated with obesity depending on multiple factors.

Keywords: Peptidyl-Dipeptidase A - genetics, Obesity - physiopathology, Mutation - genetics, Genetic Predisposition to Disease, Gene Frequency, Sex Characteristics, Polymorphism, Genetic, Body Mass Index

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750