02 October 2008
EEG coherence characteristics at rest and during a three-level working memory task in normal aging and mild cognitive impairmentZheng-Yan JiangABCDEFG, Lei-Lei ZhengCDF, En-Yan YuBG
Med Sci Monit 2008; 14(10): CR515-523 :: ID: 869414
The aim was to examine and compare the characteristics of intra- and inter-hemispheric EEG coherence in patients with mild cognitive impairment (MCI) and healthy controls at rest and during a working memory (WM) task having three levels.
Material and Method
The subjects included 35 patients with MCI according to the DSM-IV criteria (mean age: 62.3+/-6.5 years) and 34 healthy controls (mean age: 57.4+/-4.0) selected from the community. All the subjects performed a simple calculation and recall task of WM with three levels of (WM1-3) while their EEG signal was recording. Inter- and intra-hemispheric EEG coherence was analyzed during the WM loads.
Intra- and inter-hemispheric coherence during the WM task showed a "drop-to-rise" tendency compared with that at-rest condition. There was significantly higher coherence in MCI patients than in controls during the WM task. Intra-hemispheric ortical connectivity diminished while inter-hemispheric connectivity dominated in the MCI patients during WM with increasing task difficulty.
MCI patients and normal controls may have differences in cortical connection and MCI patients have a cortical connection disturbance during WM tasks. With increasing task difficulty the MCI patients mobilized more inter-hemispheric than intra-hemispheric cognitive resources.
Keywords: Psychomotor Performance, Neuropsychological Tests, Memory - physiology, Electroencephalography, Cognition Disorders - physiopathology, Aging - physiology
01 August 2022 : EditorialEditorial: Long-Term Effects of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children and the Changing Pathogenesis of Common Childhood Viruses Driven by the COVID-19 Pandemic
Med Sci Monit 2022; 28:e937927
12 Aug 2022 : Clinical ResearchRisk Factors and Pathogen Spectrum in Continuous Ambulatory Peritoneal Dialysis-Associated Peritonitis: A S...
Med Sci Monit In Press; DOI: 10.12659/MSM.937112
11 Aug 2022 : Meta-AnalysisOptimal Surgical Treatment Method for Anterior Cruciate Ligament Rupture: Results from a Network Meta-Analysis
Med Sci Monit In Press; DOI: 10.12659/MSM.937118
10 Aug 2022 : Review articleProgrammed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis
Med Sci Monit In Press; DOI: 10.12659/MSM.937766
Most Viewed Current Articles
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292