29 May 2009
Effect of meglumine antimoniate on the pancreas during treatment of visceral leishmaniasis in children
Mozhgan ShahianABCDEF, Abdolvahab AlborziADEGMed Sci Monit 2009; 15(6): CR290-293 :: ID: 869677
Abstract
Background
Pentavalent antimonials are among the first-line drugs for treating visceral leishmaniasis (VL). Acute pancreatitis is a rare toxic adverse effect of therapy with antimonial compounds in adults. This study evaluated the effect of maglumine antimoniate on the pancreas in children treated for VL.
Material and Method
A prospective study was conducted on 20 children with VL who were treated with 20 mg/kg/day maglumine antimoniate until one week after defervescence. No patient had immunosuppression caused by HIV infection, renal transplantation, or drugs. Serum levels of amylase and lipase were measured at baseline and after 2, 4, 6, 9, and12 days of therapy.
Results
During therapy, all cases had normal serum levels of amylase except for one. Serum lipase levels rose to abnormal levels in five patients, two of whom had minimally (i.e. <20% above the upper limit of normal) elevated serum lipase levels at pretreatment. All the five cases had normal serum amylase levels. There were no clinical signs or symptoms of pancreatitis in the patients.
Conclusions
It may be concluded that acute pancreatitis or hyperamylasemia are not potential complications with this therapeutic regime among immunocompetent children with VL and that routine monitoring of these patients for serum amylase and lipase levels is not necessary.
Keywords: Organometallic Compounds - therapeutic use, Meglumine - therapeutic use, Leishmaniasis, Visceral - drug therapy, Child, Preschool, Child, Antiprotozoal Agents - therapeutic use, Pancreas - drug effects
Editorial
01 March 2023 : Editorial
Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza PandemicDOI: 10.12659/MSM.939968
Med Sci Monit 2023; 29:e939968
SARS-CoV-2/COVID-19
03 March 2023 : Database Analysis
Reinfections from SARS-CoV-2: A Retrospective Study from the Gyncentrum Genetic Laboratory in Sosnowiec, Po...Med Sci Monit In Press; DOI: 10.12659/MSM.939452
09 February 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit 2023; 29:e938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
In Press
20 Mar 2023 : Clinical Research
Management of Unstable C1 Fractures Involving the Lateral Mass: Posterior C1-C2 Screw-Rod Fixation and FusionMed Sci Monit In Press; DOI: 10.12659/MSM.938600
17 Mar 2023 : Clinical Research
Relationship Between Autonomic Nervous System Activity and Axial Length in ChildrenMed Sci Monit In Press; DOI: 10.12659/MSM.939451
15 Mar 2023 : Clinical Research
Relationship Between Psychological Symptoms and Self-Esteem Levels Before and After Stomach Botox TreatmentMed Sci Monit In Press; DOI: 10.12659/MSM.939618
15 Mar 2023 : Clinical Research
Short-Term Patient Outcomes Using the Interlaminar Endoscopic Surgical System Ilessys® Delta System versus ...Med Sci Monit In Press; DOI: 10.12659/MSM.938477
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952