01 August 2009
Nephrotic-range proteinuria with small glomerular fibrillary deposits in a patient on diphenylhydantoin treatment
Ahmet Alper KiykimADE, Gultekin GenctoyBDF, Mehmet HorozADE, Sibel SariBDF, Ebru GokABF, Banu CoskunADF, Nejat YilmazADF, Iclal GursesADFMed Sci Monit 2009; 15(8): CS132-134 :: ID: 878126
Abstract
Background
Although the exact role of the diphenylhydantoin treatment on the immune system is still unclear, prolonged administration of diphenylhydantoin has been suggested to be associated with immune-based disorders and syndromes.
Material and Method
A case of fibrillary glomerulonephritis associated with DPH treatment is reported. This is the first reported case of fibrillary glomerulonephritis associated with this commonly used common anticonvulsive drug.
Results
Conclusions
A more routine surveillance for proteinuria in patients receiving DPH is recommended.
Keywords: Phenytoin - adverse effects, Periodic Acid-Schiff Reaction, Kidney Glomerulus - ultrastructure, Glomerulonephritis - pathology, Proteinuria - pathology
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