Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

31 August 2009

Statins and amiodarone improve freedom from recurrence of atrial fibrillation after successful cardioversion

Franjo NajiABCDEF, David SuranBCF, Vojko KanicAG, Damijan VokacDF, Miso SabovicADE

Med Sci Monit 2009; 15(9): CR494-498 :: ID: 878181


Amiodarone is effective in preventing atrial fibrillation (AF). Recently, the possible antiarrhythmic effects of statins have been revealed. We hypothesized that statins added to amiodarone may reduce the recurrence rate of AF after successful electrical cardioversion (EC).
Material and Method
The retrospective analysis included 198 consecutive patients (63+/-10 years; 56% men) with persistent AF (lasting at least one month, average 5.8+/-7.6 months) who underwent successful EC. All patients were put on long-time treatment with amiodarone according to standard protocol prior to EC; 50 patients (25%) also received statin therapy. AF recurrence was recorded in the following two years.
Recurrence of AF occurred less frequently in patients receiving statins and amiodarone than in those receiving amiodarone only (24 (48.0%) vs. 95 (64.1%) patients). The mean AF-free period was significantly prolonged in the statin-amiodarone group (513+/-38 days vs. 374+/-25 days, log rank test P<0.02). Cox univariate analysis showed that treatment with statins and the duration of AF before EC were significant predictors for AF recurrence. After adjustment for other potential confounders, statin therapy proved to be a statistically significant predictor of sinus rhythm maintenance (adjusted OR 0.60, 95% CI 0.38 to 0.93, P=0.02).
Our study shows that adding statins to amiodarone significantly decreases the recurrence rate of AF after successful EC in patients with persistent AF. Our findings urge for prospective randomized studies to be performed in order to confirm these results and elucidate the role of statins in AF prevention.

Keywords: Recurrence - prevention & control, Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use, Electric Countershock, Atrial Fibrillation - therapy, Anti-Arrhythmia Agents - therapeutic use, Amiodarone - therapeutic use

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

Database Analysis  

Long-Term Prognosis of Patients Undergoing Percutaneous Coronary Intervention: The Impact of Serum Creatini...

Med Sci Monit In Press; DOI: 10.12659/MSM.943063  

Database Analysis  

Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern...

Med Sci Monit In Press; DOI: 10.12659/MSM.943601  

Animal Research  

Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats

Med Sci Monit In Press; DOI: 10.12659/MSM.942485  

Clinical Research  

Differential Inflammatory Responses in Adult and Pediatric COVID-19 Patients: Implications for Long-Term Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944052  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750