Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

19 October 2009

Cyclophilin A: potential functions and therapeutic target for human cancer

Sumalee Obchoei, Sopit Wongkhan, Chaisiri Wongkham, Min Li, Qizhi Yao, Changyi Chen

Med Sci Monit 2009; 15(11): RA221-232 :: ID: 878228

Abstract

Cyclophilin A (CypA) is a cytosolic binding protein of the immunosuppressive drug cyclosporin A. CypA has an activity of peptidylprolyl cis-trans isomerase, which may play important roles in protein folding, trafficking, assembly, immune-modulator and cell signaling. Secreted form of CypA can act as growth factors in several cell types. On the other hand, CypA also involves in pathogenesis in several diseases including viral infection, cardiovascular disease and cancer. For example, CypA protein displays an unusually high expression in several cancer types and correlates with poor outcome of the patients. In this review, we have focused on the recently available clinical data of altered CypA expression in various tumor tissues and cell lines and discussed contributions and potential molecular mechanisms of CypA to tumor progression and clinical association. CypA could promote cancer cell proliferation, anti-apoptosis, cell migration/invasion and drug resistant in various cancer cell types. The mechanism by which CypA contributes to cancer progression appears to involve a complex interplay of proteins and pathways including membrane receptor for CypA, CD147, and CypA binding partners inside the cells. CypA could be used as a molecular target for cancer therapy.

Keywords: Cyclophilin A - metabolism, Neoplasms - therapy

Add Comment 0 Comments

Editorial

01 April 2025 : Editorial  

Editorial: Rapid Testing for the Avian Influenza A(H5N1) Virus is Urgently Required as Infections in Poultry and Dairy Cows are on the Rise, and so is Transmission to Humans

Dinah V. Parums

DOI: 10.12659/MSM.949109

Med Sci Monit 2025; 31:e949109

0:00

In Press

Clinical Research  

Impact of Voltage Level on Hospitalization and Mortality in Electrical Injury Cases: A Retrospective Analys...

Med Sci Monit In Press; DOI: 10.12659/MSM.947675  

0:00

Clinical Research  

Comparative Study of Plantar Load and Foot Posture Characteristics in Male Elite Squash Players and Non-Ath...

Med Sci Monit In Press; DOI: 10.12659/MSM.947828  

0:00

Clinical Research  

Dental Students’ Opinions on Use of Artificial Intelligence: A Survey Study

Med Sci Monit In Press; DOI: 10.12659/MSM.947658  

0:00

Database Analysis  

Defining Effect Size Standards in Temporomandibular Joint and Masticatory Muscle Research

Med Sci Monit In Press; DOI: 10.12659/MSM.948365  

0:00

Most Viewed Current Articles

17 Jan 2024 : Review article   8,126,196

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   703,007

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   30,250

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   24,107

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750