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21 December 2009

Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: organ-specific effects independent of antihypertensive effects

Maria do Carmo Fernandez VailatiABCDEF, Noeme Souza RochaBD, Luiz Shiguero MatsubaraABF, Carlos Roberto PadovaniC, Denise Saretta SchwartzCDE, Beatriz Bojikian MatsubaraABCDEF

Med Sci Monit 2010; 16(1): BR6-10 :: ID: 878304

Abstract

Background
The protective effect of carvedilol on multiple organ damage induced by angiotensin II (Ang II) remains unclear. The aim of this study was to evaluate the protective effect of carvedilol on the heart, liver, and kidney in rats infused with Ang II.
Material and Method
Wistar rats were randomly distributed into three groups: control (no treatment), continuously infused with Ang II (150 etag/min for 72 hr), and treated with Ang II + carvedilol (90 mg/kg/d). Histological sections of the myocardium, kidney, and liver were analyzed for the presence of necrosis.
Results
Ang II induced arterial hypertension which was not affected by carvedilol treatment (tail-cuff blood pressures, control: 125+/-13.6, Ang II: 163+/-27.3, Ang II + CV: 178+/-39.8 mmHg, p<0.05). Also, there were perivascular inflammation and necrosis in the myocardium, kidney, and hepatocytes necrosis around the terminal vein. Carvedilol treatment fully prevented damage to the heart and kidney and attenuated liver lesions induced by the Ang II infusion.
Conclusions
The protective effect of carvedilol on perivascular damage induced by Ang II infusion depended on the target organ. The prevention of heart damage occurred independently of the antihypertensive effects of carvedilol.

Keywords: Propanolamines - therapeutic use, Necrosis - pathology, Liver - pathology, Kidney - pathology, Histocytochemistry, Heart - drug effects, Carbazoles - therapeutic use, Angiotensin II - toxicity, Analysis of Variance, Systemic Vasculitis - drug therapy

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750