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01 February 2010

Serum ferritin levels correlate with hypertensive retinopathy

Erkan CobanACDEF, Erhan AlkanBG, Seher AltuntasBG, Yusuf AkarDF

Med Sci Monit 2010; 16(2): CR92-95 :: ID: 878359

Abstract

Background
In recent years several studies showed an association between body iron stores, represented by serum ferritin, and oxidative stress. The pathophysiological mechanism of hypertensive retinopathy (HR) is not fully established. Elevated blood pressure alone does not fully account for the extent of retinopathy; other pathogenic mechanisms may be involved, such as increased oxidative stress. Therefore this study was designed to determine whether ferritin levels change in HR and whether there is any relationship between the degree of HR and ferritin level.
Material and Method
This study included 72 essential hypertensive patients with HR. The hypertensive patients were divided into two groups according to the Keith-Wagener classification. Group 1 comprised 36 patients with grade I HR and group 2 36 patients with grade II HR Thirty-six normotensive healthy subjects matched for age, sex, and body mass index were selected for the control group.
Results
The level of ferritin in group 2 was significantly higher than in group 1 (92.9+/-31.8 vs. 77.8+/-23.7 ng/ml, p=0.027) and the normotensive control group (92.9+/-31.8 vs. 59.9+/-19.2 ng/ml, p=0.001). It was also higher in group 2 than in the control group (77.8+/-23.7 vs. 59.9+/-19.2 ng/ml, p=0.018). Ferritin level also showed positive correlation with the degree of HR in the hypertensive group (r=0.31, p=0.026).
Conclusions
This study suggests that there is a relationship between HR and ferritin level, which may be associated with an increased level of oxidative stress.

Keywords: Retinal Diseases - complications, Hypertension - complications, Ferritins - blood

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750