Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 June 2010

Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: A case-control study and meta-analysis

Jian-Bo ZhouBCDEF, Jin-Kui YangABCDEFG, Lei ZhaoBCF, Zhong XinBCD

Med Sci Monit 2010; 16(6): BR179-183 :: ID: 880606

Abstract

Background: Recent studies have explored several novel type 2 diabetes (T2D) susceptibility variants in the KCNQ1 (rs2237892), AP3S1 (rs3756555), MAN2A1 (rs2015698), and ALDH7A1 (rs2306617) genes in Japan and Western Africa. The aim here was to evaluate the contribution of variants in these genes to predisposition for T2D in the Chinese Northern Han population.
Material/Methods: Four candidate single-nucleotide polymorphisms (rs2237892, rs2306617, rs2015698, and rs3756555) were selected and genotyped in 537 unrelated individuals with type 2 diabetes and 510 normal controls. A meta-analysis was also done to explore the association of rs2237892 with T2D in this population.
Results: The C risk allele in rs2237892 and rs3756555 conferred significantly increased susceptibility to T2D (p=0.001, p=0.003, respectively). The significant association remained after adjusting the age, sex, and BMI (OR=1.40, 95%CI: 1.16–1.69, p=0.001; OR=1.35 95%CI: 1.11–1.63, p=0.002). No association was observed in any genetic models for rs2015698 and rs2306617. Further investigation of the control subjects using an additive model showed that fasting plasma glucose was significantly higher in the individuals with the CC genotype of rs2237892 than in those with the other two genotypes after adjusting for age, sex, and BMI (β=0.062 mmol/l per risk allele, p=0.008). The SNP of rs3756555 was marginally associated with BMI in a recessive model (p=0.05). Meta-analysis yielded an OR of 1.36 (95%CI: 1.23–1.51) for rs2237892.
Conclusions: In this study the effects of KCNQ1 and AP3S1 variants on susceptibility to T2D in the Chinese Northern Han population were confirmed.

Keywords: KCNQ1 Potassium Channel - genetics, genetic variation, Genetic Predisposition to Disease, Diabetes Mellitus, Type 2 - genetics, Case-Control Studies, Aldehyde Dehydrogenase - genetics, Adaptor Protein Complex sigma Subunits - genetics, Adaptor Protein Complex 3 - genetics, Mannosidases - genetics, Nerve Tissue Proteins - genetics, Risk

Add Comment 0 Comments

Editorial

01 July 2024 : Editorial  

Editorial: The Global Threats of Increasing Antimicrobial Resistance Require New Approaches to Drug Development, Including Molecular Antimicrobial Adjuvants

Dinah V. Parums

DOI: 10.12659/MSM.945583

Med Sci Monit 2024; 30:e945583

0:00

In Press

Clinical Research  

Reduced Radial Artery Occlusion in Transradial Cerebral Angiography: Key Predictive Factors and Preventive ...

Med Sci Monit In Press; DOI: 10.12659/MSM.944297  

0:00

Database Analysis  

Enhanced Outcomes in Femoral Subtrochanteric Fractures Using Long INTERTAN Nails with Titanium Cable Cercla...

Med Sci Monit In Press; DOI: 10.12659/MSM.944383  

0:00

Database Analysis  

Trends in HIV/AIDS-Related Mortality and the Impact of Antiretroviral Treatment Strategies in Lu'an City: A...

Med Sci Monit In Press; DOI: 10.12659/MSM.944727  

Review article  

Optimizing Quality of Life in Kidney Transplant Recipients Through Structured Exercise: A Systematic Review...

Med Sci Monit In Press; DOI: 10.12659/MSM.943617  

Most Viewed Current Articles

17 Jan 2024 : Review article   4,290,652

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,595,389

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   691,055

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,864

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750