Background: Antibiotic resistance of bacteria is on the rise and thus, the discovery of alternative therapeutic agents is urgently needed. Honey possesses good therapeutic potential, including wound healing properties and antimicrobial activity.
Case Report: The authors report on the case of a 55-year-old woman with extensive phlegmonous and necrotic lesions of the abdominal integuments and the lumbar area following traumatic colonic rupture, treated with Manuka honey wound dressings and the GENADYNE A4 negative pressure wound healing system.
Conclusions: The application of the Manuka honey and the GENADYNE A4 negative pressure wound healing system in treating phlegmonous lesions of the abdominal integuments after rupture of the colon brought good effects, ultimately enabling skin autografting on the wound site and complete wound healing.

Keywords: Rupture, Necrosis - therapy, Negative-Pressure Wound Therapy - methods, Leptospermum - chemistry, Honey, Colon - pathology, Anti-Infective Agents - therapeutic use, Wound Healing - drug effects, Wound Infection - microbiology