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28 June 2022: Clinical Research  

Impact of a Rehabilitation Program on the Change in Components of Body Mass of the Upper and Lower Limbs in People After Ischemic Stroke

Grzegorz Przysada1ACDF, Justyna Leszczak2ABEF*, Joanna Baran2CDE, Andżelina Wolan-Nieroda2BDF, Bogumiła Pniak3CDE, Viliam Knap4BDF, Mariusz Drużbicki2ADF, Agnieszka Guzik2ADE

DOI: 10.12659/MSM.936397

Med Sci Monit 2022; 28:e936397

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Abstract

BACKGROUND: The aim of this study was to evaluate the effects of rehabilitation in terms of changes in the body mass composition in the upper and lower limbs depending on the length of time after stroke and the age of the patient.

MATERIAL AND METHODS: Eighty-two patients after ischemic stroke were tested 3 times: on admission, after 5 weeks, and 3 months after leaving the hospital (follow-up). During each examination, a segmental analysis of the components of the body mass of the upper limbs and lower limbs was performed, depending on the side of paresis.

RESULTS: Patients between 7 and 12 months after stroke with right-sided paresis had a reduction of fat (P=0.027) and an increase in muscle tissue in the lower (P=0.030) and upper limbs with paresis (P=0.037), as well as in the healthy upper limb (P=0.034) after rehabilitation. Only in the youngest age group (25-44 years) and in patients with left-sided paresis was there a decrease of adipose tissue in the healthy upper (P=0.012) and paresis limbs (P=0.032) and an increase in the muscle tissue mass in the right upper limb (P=0.010) after rehabilitation.

CONCLUSIONS: The rehabilitation program had a significant impact on the change in the composition of body mass in upper and lower limbs in people with right-sided paresis, particularly 7 to 12 months after stroke and in the youngest age group (25-44 years). These results may be useful in planning a rehabilitation program for stroke patients to consider the patient’s dominant hand and neglect.

Keywords: Adipose Tissue, Body Composition, Follow-Up Studies, ischemic stroke, Neoplasms, Muscle Tissue, Paresis, Rehabilitation

Background

Stroke is currently an increasingly common cause of permanent disability worldwide. A stroke incident leads to permanent disability, with people often requiring assistance from third parties after stroke, and can even lead to death [1,2].

Worldwide, approximately 17 million people have a stroke each year, and in Poland the incidence of ischemic stroke is estimated at around 90 000 cases [3]. Stroke is the second most common cause of death in the world after ischemic heart disease and is often associated with various long-term physical and neuropsychological consequences [4–6]. Despite the decrease in mortality due to stroke observed in recent years, the global burden of stroke is increasing. A more comprehensive approach to primary stroke prevention is needed as is the timely start of comprehensive rehabilitation [7,8].

The literature points out that the body mass composition of patients after stroke should also be considered in the rehabilitation process [9,10]. Early rehabilitation allows for the return of lost functions by, among other things, faster muscle mass growth [11]. After a stroke, there is a reduction in muscle mass, loss of fat-free mass and bone mineral content, and increased adipose tissue (fat) [12,13]. This results in a reduction in functional efficiency in patients after stroke. It is also interesting that few researchers note in their reports that stroke and hemiparesis are associated with changes in the body composition of the limbs, especially bone and fat-free mass. They show that a stroke is likely to cause an increase in the fat mass of the trunk, but not in the limbs [14].

Studies indicate that the greatest progress in the recovery of functional fitness can be expected in the early period after stroke, when patients often show a significant improvement in neuromotor functions [15,16], this process slows down later, and patients tend to present persistent patterns [17, 18]. Nevertheless, numerous studies have reported that inter-neuronal connections can be continuously remodelled by physical activity, and that brain plasticity can be increased through various types of training [19–22]. Moreover, age has also been reported to influence the achievement of positive brain plasticity results during motor training [23].

There are reports in the literature on the effects of rehabilitation depending on the time after stroke [24,25] or age [26–29], and to the best of our knowledge, there are no studies on the effects of rehabilitation in terms of changes in the body mass composition depending on the length of time after stroke and patient age. Therefore, the aim of the study was to evaluate the effects of rehabilitation in terms of changes in the body mass composition in the upper and lower limbs depending on time after stroke and age of the patients.

Material and Methods

TYPE OF STUDY:

This was a prospective observational study. The study was conducted in accordance with the Helsinki Declaration, and it was approved by the local bioethics commission (approval no. 2015/10/03). Written consent was obtained from all participants in the study.

PARTICIPANTS AND INCLUSION AND EXCLUSION CRITERIA:

During the research period, 403 patients after stroke were in the Rehabilitation Clinic’s Early Neurological Rehabilitation Unit. Prior to the study, a sample size was calculated from the 403 patients who were in the clinic during this period. With a 95% confidence interval, a significance level of 0.05, and a maximum error of 10%, it was calculated that the minimum sample size should be 78. Considering the inclusion and exclusion criteria, the study included 82 patients after ischemic stroke staying in the Rehabilitation Clinic’s Early Neurological Rehabilitation Unit.

The inclusion criteria for the entire study group were as follows: diagnosis of ischemic stroke, first complete stroke, the ability to stand without assistance, walking independently without the help of other people (including a doctor, nurse, physiotherapist) or with a little ankle-foot orthosis type support, no impairment of higher mental functions, right-handedness, completion of a 5-week inpatient rehabilitation program, informed consent to participate in the study, and age ≥25 years.

The inclusion criteria in examination III (follow-up) were as follows: physical activity measured by the self-report physical activity questionnaire (SPAQ) at a low-intensity level, not using additional rehabilitation between examination II and examination III, and appearing for a follow-up visit 3 months after discharge from the hospital.

The exclusion criteria for the whole study group were as follows: lack of consent of the patient to participate in the study, incomplete stroke (eg, transient ischemic attack), hemorrhagic stroke, second or subsequent stroke, inability to stand independently (balance disorders and dizziness), ischemic lesion located in the cerebellum and brainstem, electronic implants, epilepsy, pregnancy, menstruation in women, and leg injuries after stroke.

MEASUREMENTS: Patients were divided into 4 age groups: young age was from 25 to 44 years, middle age was from 44 to 60 years, elderly age was 60 to 75 years, senile age was ≥75 years [30]. Considering the time since stroke in the study group, there were patients who were in the early and late periods after stroke. In assessing the effects of rehabilitation on changes in the body mass of the upper and lower limbs depending on the time after stroke, the group of patients was divided according to time after stroke as follows: 2 to 3 months, 4 to 6 months, 7 to 12 months, and >12 months [31]. Patients were also divided by sex (Table 1).

The body mass composition of patients was evaluated with the 780 MA Tanita MC analyzer, which is based on the measurement of electrical bioimpedance [32,33]. The analyzer is able to carry out a segmental body assessment, including of adipose tissue (fat) and muscle mass, which is divided into right and left arm, right and left leg, and trunk. The body height was measured to within 0.1 cm using the portable PORTSTAND 210. Measurements were made under standard conditions. Patients wore underwear and no shoes and were instructed to assume an upright posture. The analyzer is approved for medical use and meets the Non-Automatic Weighing Instrument Class III standards for scales used for medical measurements. The analyzer has European Union CE0122 certification. With regard to medical devices, it meets the requirements of the Medical Device Directive 93/42/EEC.

PROCEDURE:

All patients participated in a 5-week rehabilitation program that lasted 5 days a week, from Monday to Friday. The rehabilitation program was based on neurodevelopmental methods, gait and upper limb training, as well as exercises on equipment using biological feedback and static and dynamic parapodium. The tests were performed 3 times: the first test (examination I) was performed at admission to the clinic prior to rehabilitation. A second test (examination II) was performed at discharge after 5 weeks of hospital rehabilitation. The third test (examination III) was performed as a follow-up 3 months after leaving the clinic during a follow-up visit.

After examination II, rehabilitation activities were limited to the recommendations that the patients and family members received upon discharge from the hospital from the therapeutic team; the patients did not use additional rehabilitation in the period between examinations II and III. An additional recommendation was to maintain physical activity at least at a low-intensity level, including basic everyday activities, light housework, light gardening, grocery shopping, and leisurely walks (according to the SPAQ) [34,35].

Inclusion criteria were developed for all 3 examinations (examination I, examination II, examination III), and additionally (and separately) for examination III (follow-up), with a 3-month interval between measurement II and measurement III.

STATISTICAL ANALYSIS:

The results are presented using descriptive statistics (mean, standard deviation, quartile). When analyzing the differences between the dependent variables, the t test for dependent samples was used, after prior verification of the normality of the distributions of the variables with the Kolmogorov-Smirnov test. Correlations between the variables were assessed by the Pearson correlation coefficient. A significance level of P<0.05 was used. The calculation was performed with the STATISTICA package version 10.0 (StatSoft).

Results

The change in fat content of the patients was analyzed as a whole and divided into lower right, lower left, upper right, and upper left limbs, taking into account the age of the patients and the side of the paresis. It was noted that people with left-sided paresis who were in the youngest age group (25–44 years) had a reduction in the fat content of the healthy (P=0.012) and paresis upper limbs (P=0.032; Table 2). In older age groups, there was no statistically significant change in fat content between examinations I and II and examinations II and III (Table 3). In view of the patients’ fat content, it was noted that in left-sided paresis in the youngest age group (25–44 years), the muscle tissue content in the upper right (healthy) limb (P=0.010) was increased after rehabilitation. In addition, the control study found a decrease in the overall muscle tissue content, including in people with left-sided paresis (P=0.049; Table 4).

Results of the follow-up examination showed that in people with left-sided paresis at the age of 61 to 75 years, the muscle content of the healthy lower limb was significantly reduced (P=0.048; Table 5).

The changes in body mass of the persons after stroke were then analyzed and considered the time elapsed since the stroke incident and the side of paresis. We found that in the period from 2 to 3 months after stroke and with left-sided paresis, there was a reduction in the content of adipose tissue in the paresis upper limb (P=0.047; Table 6)

Many more changes were seen among patients between 7 and 12 months after stroke. In patients with right-sided paresis, the fat content of the lower paresis limb (P=0.027), the upper paresis limb (P=0.023), and the healthy upper limb (P=0.033) decreased after rehabilitation. Among patients with left-sided paresis, an increase in the fat content of the lower paresis limb was observed (P=0.028). A similar result was observed in the lower heathy limb in patients who were at least 12 months after stroke (P=0.042). In the follow-up examination in people more than 12 months after stroke with left-sided paresis, the level of fat in the healthy lower limb increased (Table 7).

The analysis of the change in muscle tissue content due to rehabilitation did not show any statistically significant changes in patients between 2 and 3 months after stroke, as well as in patients between 4 and 6 months after the onset of the stroke incident (Table 8).

In contrast, in patients between 7 and 12 months after stroke with right-sided paresis, an increase in muscle tissue content in the lower paresis limb (P=0.030), upper paresis limb (P=0.037), and healthy upper limb (P=0.034) was observed, which indicated a positive result of the rehabilitation. In people with left-sided paresis more than 12 months after stroke, muscle tissue was reduced in the healthy limbs (Table 9).

Discussion

LIMITATIONS:

Despite our efforts, this study had certain limitations. First, the analysis was carried out only among patients who had ischemic stroke and only in right-handed patients. In subsequent studies, the group will be expanded to include patients with hemorrhagic stroke and left-handedness. The second limitation may be the segmental assessment of only the adipose and muscle tissue in the limbs of patients after a stroke with regard to age and time since stroke. However, the study did not consider the body mass composition of the whole body, owing to the isolation and evaluation of the effects of rehabilitation in terms of changes in the body mass composition in the upper and lower limbs. An interesting analysis could also be the assessment of the correlation between the body mass composition and the level of physical activity in patients after stroke. It would be worth considering the inclusion of such analysis in future studies.

Conclusions

The rehabilitation program has had a significant impact on the change in the composition of body mass in upper limbs and lower limbs in people with right-sided paresis, in particular 7 to 12 months after stroke. We suspect that this may have been because the patients were right-handed and therefore their exercise was intensified in the upper and lower right limbs. The results obtained may be useful in planning a rehabilitation program for stroke patients that considers the patient’s dominant side and neglect.

Under the influence of hospital rehabilitation in the youngest age group (25–44 years) muscle tissue growth was observed, and adipose tissue was reduced in the upper limbs in patients with left-sided paresis. This may indicate the need for specific activation of older people who are more likely to have coexisting diseases and lower functional efficiency than those of a younger age.

References

1. The Lancet: Lancet, 2018; 392(10154); 1167

2. Błażejewska-Hyżorek B, Członkowska A, Czernuszenko A, Stroke management guidelines: Pol Przegl Neurol, 2019; 15(Suppl A); 1-156

3. Filipska K, Skrzypek-Czerko M, Cwiekala-Lewis K, Ślusarz R, Clinimetric evaluation of functional capacity and quality of life of stroke patients – study review: J Neurol Neurosurg Nurs, 2019; 8; 86-90

4. Donkor ES: Stroke Res Treat, 2018; 2018; 3238165

5. NFZ on Health: Ischemic Stroke, 2019 (cited 2021,15 November). Available fromhttps://zdrowedane.nfz.gov.pl/pluginfile.php/202/mod_resource/content/1/udar_niedokrwienny_mozgu_nfz_o_zdrowiu.pdf

6. Hankey GJ, Stroke: Lancet, 2017; 389; 641-54

7. Coleman ER, Moudgal R, Lang K, Early rehabilitation after stroke: A narrative review: Curr Atheroscler Rep, 2017; 19; 59

8. Irisawa H, Mizushima T, Correlation of body composition and nutritional status with functional recovery in stroke rehabilitation patients: Nutrients, 2020; 12; 1923

9. Przysada G, Czenczek-Lewandowska E, Wyszyńska J, Effect of post-stroke rehabilitation on body mass composition in relation to socio-demographic and clinical factors: Int J Environ Res Public Health, 2020; 17; 5134

10. Pollock A, Baer G, Campbell P, Physical rehabilitation approaches for the recovery of function and mobility following stroke: Cochrane Database Syst Rev, 2014; 22; CD001920

11. Scherbakov N, Pietrock C, Sandek A, Body weight changes and incidence of cachexia after stroke: J Cachexia Sarcopenia Muscle, 2019; 10; 611-20

12. Celik B, Ones K, Ince N, Body composition after stroke: Intern J Rehabil Res, 2008; 31; 93-96

13. Chang KV, Wu WT, Huang KC, Han DS, Segmental body composition transitions in stroke patients: Trunks are different from extremities and strokes are as important as hemiparesis: Clin Nutr, 2020; 39(6); 1968-73

14. Duncan PW, Lai SM, Keighley J, Defining post-stroke recovery: Implications for design and interpretation of drug trials: Neuropharmacology, 2000; 39(5); 835-41

15. Lee KB, Lim SH, Kim KH, Six-month functional recovery of stroke patients: A multi-time-point study: Int J Rehabil Res, 2015; 38(2); 173-80

16. Dąbrowski J, Czajka A, Zielińska-Turek J, Brain functional reserve in the context of neuroplasticity after stroke: Neural Plast, 2019; 2019; 9708905

17. Kopp B, Kunkel A, Mühlnickel W, Villringer K, Taub E, Flor H, Plasticity in the motor system related to therapy-induced improvement of movement after stroke: Neuroreport, 1999; 10(4); 807-10

18. Ruge D, Liou LM, Hoad D, Improving the potential of neuroplasticity: J Neurosci, 2012; 32(17); 5705-6

19. Ploughman M, Review of the literature on brain neuroplasticity and its implications for physiotherapy of stroke: Rehabil Med, 2003; 7; 15-27

20. Pandian S, Arya KN, Kumar D, Does motor training of the nonparetic side influences balance and function in chronic stroke? A pilot RCT: Sci World J, 2014; 2014; 769726

21. Luft AR, Macko RF, Forrester LW, Treadmill exercise activates subcortical neural networks and improves walking after stroke: A randomized controlled trial: Stroke, 2008; 39(12); 3341-50

22. Mahncke HW, Bronstone A, Merzenich MM, Brain plasticity and functional losses in the aged: scientific bases for a novel intervention: Prog Brain Res, 2006; 157; 81-109

23. Sawaki L, Butler AJ, Leng X, Differential patterns of cortical reorganization following constraint-induced movement therapy during early and late period after stroke: A preliminary study: NeuroRehabilitation, 2014; 35(3); 415-26

24. Wolf SL, Thompson PA, Winstein CJ, The EXCITE stroke trial: Comparing early and delayed constraint-induced movement therapy: Stroke, 2010; 41(10); 2309-15

25. Bagg S, Pombo AP, Hopman W, Effect of age on functional outcomes after stroke rehabilitation: Stroke, 2002; 33(1); 179-85

26. Bindawas SM, Vennu V, Mawajdeh H, Alhaidary H, Functional outcomes by age after inpatient stroke rehabilitation in Saudi Arabia: Clin Interv Aging, 2017; 12; 1791-97

27. Yoo JW, Hong BY, Jo L, Effects of age on long-term functional recovery in patients with stroke: Medicina (Kaunas), 2020; 56(9); 451

28. Park SY, Lee IH, The influence of age, lesion side and location on rehabilitation outcomes after stroke: J Phys Ther Sci, 2011; 23; 817-19

29. Wilczyński J, Pedrycz A, Mucha D, Body posture, postural stability, and metabolic age in patients with Parkinson’s disease: Biomed Res Int, 2017; 2017; 3975417

30. Dyussenbayev A, Age periods of human life: Adv Soc Sci Res J, 2017; 4(6); 2924

31. Dromerick AW, Geed S, Barth J, Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans: Proc Natl Acad Sci USA, 2021; 118(39); e2026676118

31. Leszczak J, Czenczek-Lewandowska E, Przysada G, Association between body mass index and results of rehabilitation in patients after stroke: A 3-month observational follow-up study: Med Sci Monit, 2019; 25; 4869-76

32. Anyżewska A, Lepionka T, Łakomy R, Fat Mass Index and dietary behaviours of the Polish Border Guard officers: Rocz Panstw Zakl Hig, 2019; 70; 201-8

33. Phusuttatam T, Saengsuwan J, Kittipanya-Ngam P, Development and preliminary validation of a stroke physical activity questionnaire: Stroke Res Treat, 2019; 2019; 6764834

34. Potchana K, Saengsuwan J, Kittipanya-Ngam P, Validity and test-retest reliability of a thai stroke physical activity questionnaire: J Stroke Cerebrovasc Dis, 2021; 30(8); 105907

35. English C, Thoirs K, Coates A, Ryan A, Bernhardt J, Changes in fat mass in stroke survivors: A systematic review: Int J Stroke, 2012; 7(6); 491-98

36. Beaupre GS, Lew HL, Bone-density changes after stroke: Am J Phys Med Rehabil, 2006; 85; 464-72

37. Scherbakov N, Sandek A, Doehner W, Stroke-related sarcopenia: Specific characteristics: J Am Med Dir Assoc, 2015; 16; 272-76

38. Scherbakov N, von Haehling S, Anker SD, Stroke induced Sarcopenia: Muscle wasting and disability after stroke: Int J Cardiol, 2013; 170; 89-94

39. Altieri M, Maestrini I, Mercurio A, Depression after minor stroke: Prevalence and predictors: Eur J Neurol, 2012; 19(3); 517-21

40. Schöttke H, Giabbiconi CM, Post-stroke depression and post-stroke anxiety: Prevalence and predictors: Int Psychogeriatr, 2015; 27(11); 1805-12

41. Jiang XG, Lin Y, Li YS, Correlative study on risk factors of depression among acute stroke patients: Eur Rev Med Pharmacol Sci, 2014; 18(9); 1315-23

42. Jehkonen M, Yliranta A, Rasimus S, Saunamäki TNeglect rehabilitation after stroke: Duodecim, 2013; 129(5); 506-13 [in Finnish]

43. Luukkainen-Markkula R, Tarkka IM, Pitkänen K, Rehabilitation of hemispatial neglect: A randomized study using either arm activation or visual scanning training: Restor Neurol Neurosci, 2009; 27(6); 663-72

44. Matano A, Iosa M, Guariglia C, Does outcome of neuropsychological treatment in patients with unilateral spatial neglect after stroke affect functional outcome?: Eur J Phys Rehabil Med, 2015; 51(6); 737-43

45. Chen P, Chen CC, Hreha K, Kessler Foundation Neglect Assessment Process uniquely measures spatial neglect during activities of daily living: Arch Phys Med Rehabil, 2015; 96(5); 869-76e1

46. van Wyk A, Eksteen CA, Rheeder P, The effect of visual scanning exercises integrated into physiotherapy in patients with unilateral spatial neglect poststroke: A matched-pair randomized control trial: Neurorehabil Neural Repair, 2014; 28(9); 856-73

48. Ha L, Hauge T, Iversen PO, Body composition in older acute stroke patients after treatment with individualized, nutritional supplementation while in hospital: BMC Geriatr, 2010; 10; 75

49. Brynningsen PK, Damsgaard EM, Husted SE, Improved nutritional status in elderly patients 6 months after stroke: J Nutr Health Aging, 2007; 11(1); 75-79

50. Irisawa H, Mizushima T, Correlation of body composition and nutritional status with functional recovery in stroke rehabilitation patients: Nutrients, 2020; 12(7); 1923

51. Vahlberg B, Lindmark B, Zetterberg L, Body composition and physical function after progressive resistance and balance training among older adults after stroke: An exploratory randomized controlled trial: Disabil Rehabil, 2017; 39(12); 1207-14

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