21 October 2019 : Laboratory Research
Antiproliferative Activity of Carnosic Acid is Mediated via Inhibition of Cell Migration and Invasion, and Suppression of Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway
DOI: 10.12659/MSM.917735
Med Sci Monit 2019; 25:7864-7871
Related articles
01 Feb 2020 : Laboratory Research
Bauerane Induces S-Phase Cell Cycle Arrest, Apoptosis, and Inhibition of Proliferation of A549 Human Lung Cancer Cells Through the Phosphoinositide 3-Kinase (PI3K)/AKT and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway
Qin Chen, Ming Wang
DOI: 10.12659/MSM.919558
Med Sci Monit 2020; 26:e919558
02 Jan 2020 : Laboratory Research
S100A16 Regulates HeLa Cell through the Phosphatidylinositol 3 Kinase (PI3K)/AKT Signaling Pathway
Haibin Zhang, Yongxiu Yang
DOI: 10.12659/MSM.919757
Med Sci Monit 2020; 26:e919757
28 Feb 2020 : Laboratory Research
Synaptotagmin 12 (SYT12) Gene Expression Promotes Cell Proliferation and Progression of Lung Adenocarcinoma and Involves the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway
Kaichao Liu, Jing Luo
DOI: 10.12659/MSM.920351
Med Sci Monit 2020; 26:e920351
21 Jul 2020 : Laboratory Research
Silencing of Long Non-Coding RNA (LncRNA) Non-Coding RNA Activated by DNA Damage (NORAD) Inhibits Proliferation, Invasion, Migration, and Promotes Apoptosis of Glioma Cells via Downregulating the Expression of AKR1B1
Lun Luo, Chuan Chen
DOI: 10.12659/MSM.922659
Med Sci Monit 2020; 26:e922659
28 Apr 2020 : Animal Research
Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum(II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) Pathway
KeBin Lu, Wenjun Wei
DOI: 10.12659/MSM.922518
Med Sci Monit 2020; 26:e922518
16 Jun 2019 : Laboratory Research
Formiminotransferase Cyclodeaminase Suppresses Hepatocellular Carcinoma by Modulating Cell Apoptosis, DNA Damage, and Phosphatidylinositol 3-Kinases (PI3K)/Akt Signaling Pathway
Jiajia Chen, Zemian Chen
DOI: 10.12659/MSM.916202
Med Sci Monit 2019; 25:4474-4484
10 Jun 2019 : Laboratory Research
microRNA-378a Regulates the Reactive Oxygen Species (ROS)/Phosphatidylinositol 3-Kinases (PI3K)/AKT Signaling Pathway in Human Lens Epithelial Cells and Cataract
Yan Liu, Huanhuan Li
DOI: 10.12659/MSM.916881
Med Sci Monit 2019; 25:4314-4321
05 Aug 2019 : Laboratory Research
Salidroside Suppresses IL-1β-Induced Apoptosis in Chondrocytes via Phosphatidylinositol 3-Kinases (PI3K)/Akt Signaling Inhibition
Mingzheng Wu, Rui Hu
DOI: 10.12659/MSM.917851
Med Sci Monit 2019; 25:5833-5840
25 Mar 2019 : Clinical Research
Neuro-Protective Role of Metformin in Patients with Acute Stroke and Type 2 Diabetes Mellitus via AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Pathway and Oxidative Stress
Min Zhao, Xiao Wan Li
DOI: 10.12659/MSM.911250
Med Sci Monit 2019; 25:2186-2194
02 Oct 2019 : Clinical Research
Tivantinib Hampers the Proliferation of Glioblastoma Cells via PI3K/Akt/Mammalian Target of Rapamycin (mTOR) Signaling
Yukun Wu, Zhizhang Li
DOI: 10.12659/MSM.919319
Med Sci Monit 2019; 25:7383-7390
01 Jan 2019 : Laboratory Research
Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating β-Catenin Signaling
Lei Wang, Saie Shen
DOI: 10.12659/MSM.911503
Med Sci Monit 2019; 25:21-31
17 Feb 2019 : Laboratory Research
Phosphatase Actin Regulator-1 (PHACTR-1) Knockdown Suppresses Cell Proliferation and Migration and Promotes Cell Apoptosis in the bEnd.3 Mouse Brain Capillary Endothelial Cell Line
Yao Jing, Lin Zhang
DOI: 10.12659/MSM.912586
Med Sci Monit 2019; 25:1291-1300
03 Jan 2019 : Laboratory Research
Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway
Lin Chen, Guangsheng Yang
DOI: 10.12659/MSM.912929
Med Sci Monit 2019; 25:77-86
17 Mar 2019 : Laboratory Research
Murrayanine Induces Cell Cycle Arrest, Oxidative Stress, and Inhibition of Phosphorylated p38 Expression in A549 Lung Adenocarcinoma Cells
Jingbao Zhang, Yanfei Gao
DOI: 10.12659/MSM.913873
Med Sci Monit 2019; 25:2002-2008
04 Jun 2019 : Animal Research
Loganin Attenuates Osteoarthritis in Rats by Inhibiting IL-1β-Induced Catabolism and Apoptosis in Chondrocytes Via Regulation of Phosphatidylinositol 3-Kinases (PI3K)/Akt
Yi Yang, Yuntao Gu
DOI: 10.12659/MSM.915064
Med Sci Monit 2019; 25:4159-4168
04 Sep 2019 : Laboratory Research
Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the Phosphatidylinositol 3-Kinases (PI3K)/Akt/Nuclear Factor kappa B (NF-κB) Signaling Pathway
Dong Fang, Zhaoguang Lai
DOI: 10.12659/MSM.915075
Med Sci Monit 2019; 25:6639-6648
19 Jun 2019 : Clinical Research
Proliferation of Ovarian Granulosa Cells in Polycystic Ovarian Syndrome Is Regulated by MicroRNA-24 by Targeting Wingless-Type Family Member 2B (WNT2B)
Zhong Yuanyuan, Wang Zeqin
DOI: 10.12659/MSM.915320
Med Sci Monit 2019; 25:4553-4559
08 Jul 2019 : Laboratory Research
Parthenolide Inhibits the Proliferation of MDA-T32 Papillary Thyroid Carcinoma Cells in Vitro and in Mouse Tumor Xenografts and Activates Autophagy and Apoptosis by Downregulation of the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Signaling Pathway
Chao Li, Yuqiu Zhou
DOI: 10.12659/MSM.915387
Med Sci Monit 2019; 25:5054-5061
20 Aug 2019 : Laboratory Research
SOX18 Affects Cell Viability, Migration, Invasiveness, and Apoptosis in Hepatocellular Carcinoma (HCC) Cells by Participating in Epithelial-to-Mesenchymal Transition (EMT) Progression and Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR)
Yanni Sun, Bo Lei
DOI: 10.12659/MSM.915729
Med Sci Monit 2019; 25:6244-6254
08 Jun 2019 : Laboratory Research
Knockdown of Hypoxia-Inducible Factor 1α (HIF-1α) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells
Jinling Huang, Likun Gao
DOI: 10.12659/MSM.915730
Med Sci Monit 2019; 25:4250-4263
28 Aug 2019 : Animal Research
High-Mobility Group Box 1 (HMGB1) Induces Migration of Endothelial Progenitor Cell via Receptor for Advanced Glycation End-Products (RAGE)-Dependent PI3K/Akt/eNOS Signaling Pathway
Yulong Zhang, Bo You
DOI: 10.12659/MSM.915829
Med Sci Monit 2019; 25:6462-6473
05 Sep 2018 : Laboratory Research
Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway
Haitao Sun, Mengfan Yin
DOI: 10.12659/MSM.910201
Med Sci Monit 2018; 24: LBR6178-6186
12 Jun 2018 : Laboratory Research
Role of Hydroxysteroid Dehydrogenase-Like 2 (HSDL2) in Human Ovarian Cancer
Qing Sun, Yilin Zhang
DOI: 10.12659/MSM.909418
Med Sci Monit 2018; 24: LBR3997-4008
28 Oct 2018 : Clinical Research
Long Non-Coding RNA (lncRNA) Growth Arrest Specific 5 (GAS5) Suppresses Esophageal Squamous Cell Carcinoma Cell Proliferation and Migration by Inactivating Phosphatidylinositol 3-kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway
Guojun Wang, Junfeng Sun
DOI: 10.12659/MSM.910867
Med Sci Monit 2018; 24: CLR7689-7696
10 Apr 2018 : Laboratory Research
Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway
Jiawen You, Jun Cheng
DOI: 10.12659/MSM.909627
Med Sci Monit 2018; 24: LBR2126-2133
01 Oct 2018 : Laboratory Research
Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways
Chenlin Pei, Qun He
DOI: 10.12659/MSM.911013
Med Sci Monit 2018; 24: LBR6975-6983
18 Mar 2018 : Animal Research
Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage
Wenqian Zhang, Ying Cui
DOI: 10.12659/MSM.905700
Med Sci Monit 2018; 24: ANS1588-1596
05 Feb 2018 : Laboratory Research
lncRNA BG981369 Inhibits Cell Proliferation, Migration, and Invasion, and Promotes Cell Apoptosis by SRY-Related High-Mobility Group Box 4 (SOX4) Signaling Pathway in Human Gastric Cancer
Xiuli Dong, Renpin Chen
DOI: 10.12659/MSM.905965
Med Sci Monit 2018; 24: MOL718-726
11 Nov 2018 : Laboratory Research
Silencing the FOLR2 Gene Inhibits Cell Proliferation and Increases Apoptosis in the NCI-H1650 Non-Small Cell Lung Cancer Cell Line via Inhibition of AKT/Mammalian Target of Rapamycin (mTOR)/Ribosomal Protein S6 Kinase 1 (S6K1) Signaling
Xiaohua Xu, Jianyang Jiang
DOI: 10.12659/MSM.911384
Med Sci Monit 2018; 24: LBR8064-8073
31 Jan 2018 : Laboratory Research
Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma
Peng Li, Hongliang Liu
DOI: 10.12659/MSM.908076
Med Sci Monit 2018; 24: LBR623-635
21 Nov 2018 : Laboratory Research
miR-339-5p Increases Radiosensitivity of Lung Cancer Cells by Targeting Phosphatases of Regenerating Liver-1 (PRL-1)
Jia Wang, Mawei Jiang
DOI: 10.12659/MSM.910808
Med Sci Monit 2018; 24: LBR8408-8416
12 Oct 2018 : Laboratory Research
Anticancer Activity of Mukonal Against Human Laryngeal Cancer Cells Involves Apoptosis, Cell Cycle Arrest, and Inhibition of PI3K/AKT and MEK/ERK Signalling Pathways
Liu Li, Lu Huizhi
DOI: 10.12659/MSM.910702
Med Sci Monit 2018; 24: LBR7295-7302
07 Oct 2018 : Laboratory Research
Gambogic Acid Induces Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells by Suppressing Notch Signaling
Minghua Zhu, Minjie Wang
DOI: 10.12659/MSM.912563
Med Sci Monit 2018; 24: LBR7146-7151
19 Sep 2018 : Animal Research
Protective Effects of Oleuropein Against Cerebral Ischemia/Reperfusion by Inhibiting Neuronal Apoptosis
Weijing Zhang, Xiaogang Liu
DOI: 10.12659/MSM.912336
Med Sci Monit 2018; 24: ANS6587-6598
11 Feb 2018 : Laboratory Research
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway
Er-Min Wang, Qiu-Ling Fan
DOI: 10.12659/MSM.907814
Med Sci Monit 2018; 24: LBR846-854
18 Sep 2018 : Laboratory Research
Anticancer Activity of Phloretin Against Human Gastric Cancer Cell Lines Involves Apoptosis, Cell Cycle Arrest, and Inhibition of Cell Invasion and JNK Signalling Pathway
Min Xu, Weiguang Gu
DOI: 10.12659/MSM.910542
Med Sci Monit 2018; 24: LBR6551-6558
19 Oct 2018 : Animal Research
Mangiferin Potentiates Neuroprotection by Isoflurane in Neonatal Hypoxic Brain Injury by Reducing Oxidative Stress and Activation of Phosphatidylinositol-3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling
Jia-shui Xi, Yu-fen Wang
DOI: 10.12659/MSM.908142
Med Sci Monit 2018; 24: ANS7459-7468
09 Sep 2018 : Laboratory Research
Marsdenia Tenacissima Extract Inhibits Proliferation and Promotes Apoptosis in Human Ovarian Cancer Cells
Yuhong Zhang, Yangjia Zhang
DOI: 10.12659/MSM.909726
Med Sci Monit 2018; 24: LBR6289-6297
27 Aug 2018 : Clinical Research
MicroRNA-495 Confers Increased Sensitivity to Chemotherapeutic Agents in Gastric Cancer via the Mammalian Target of Rapamycin (mTOR) Signaling Pathway by Interacting with Human Epidermal Growth Factor Receptor 2 (ERBB2)
Na Li, Mei Han
DOI: 10.12659/MSM.909458
Med Sci Monit 2018; 24: CLR5960-5972
16 Jul 2018 : Laboratory Research
The Effects of Ludartin on Cell Proliferation, Cell Migration, Cell Cycle Arrest and Apoptosis Are Associated with Upregulation of p21WAF1 in Saos-2 Osteosarcoma Cells In Vitro
Shuang-li Zhang, Bao-lin Li
DOI: 10.12659/MSM.909193
Med Sci Monit 2018; 24: LBR4926-4933
14 Feb 2017 : Animal Research
Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease
Lijuan Zhang, Lina Wang
DOI: 10.12659/MSM.898679
Med Sci Monit 2017; 23:801-808
Editorial
01 July 2022 : Editorial
Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Response to the Global Spread of Lineages and Sublineages of Omicron, or B.1.1.529, SARS-CoV-2DOI: 10.12659/MSM.937676
Med Sci Monit 2022; 28:e937676
SARS-CoV-2/COVID-19
27 June 2022 : Clinical Research
Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...Med Sci Monit In Press; DOI: 10.12659/MSM.937430
04 June 2022 : Clinical Research
Screening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...Med Sci Monit 2022; 28:e936962
30 May 2022 : Clinical Research
Effects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...Med Sci Monit 2022; 28:e936069
27 May 2022 : Clinical Research
Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)Med Sci Monit 2022; 28:e936547
In Press
01 Jul 2022 : Clinical Research
Does Early-Period Patient Dissatisfaction Turn Into Satisfaction Over Time After Total Knee Replacement?Med Sci Monit In Press; DOI: 10.12659/MSM.936792
30 Jun 2022 : Laboratory Research
Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...Med Sci Monit In Press; DOI: 10.12659/MSM.936760
30 Jun 2022 : Clinical Research
Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip ArthroplastyMed Sci Monit In Press; DOI: 10.12659/MSM.936335
28 Jun 2022 : Meta-Analysis
Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-AnalysisMed Sci Monit In Press; DOI: 10.12659/MSM.937166
Most Viewed Current Articles
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review article
Long-Term Respiratory and Neurological Sequelae of COVID-19DOI :10.12659/MSM.928996
Med Sci Monit 2020; 26:e928996
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952